The present study aimed to design and validate a conceptual model of the skill-oriented university using an exploratory mixed-method approach. In the qualitative phase, based on the grounded theory approach of Strauss and Corbin, data were collected through 20 semi-structured interviews with faculty members of the University of Urmia and analyzed using MAXQDA software through three stages of open, axial, and selective coding. The findings of this phase led to the identification of five main components, including curriculum reorganization, human resource empowerment, strengthening external interactions, infrastructure and technology redesign, and institutional policymaking and support. In the quantitative phase, to validate the extracted conceptual model, the statistical population included all students of the University of Urmia, among whom 250 individuals were selected through proportionate stratified random sampling. Data were collected using a researcher-made questionnaire developed based on the qualitative findings and analyzed by SmartPLS3 software. The results indicated that all components had significant effects on achieving a skill-oriented university, and the overall model fit index (GOF=0.466) confirmed the validity and theoretical coherence of the final model. Accordingly, the proposed model can serve as a localized and practical framework for guiding universities toward skill orientation and enhancing students’ employability, providing valuable insights for higher education policymakers