The aim of the study is analyzing the relationship between teacher self-efficacy and innovative teaching with the mediating role of teaching motivation and emotional exhaustion amon faculty members of Urmia University. The research method is descriptive-correlation type of structural equations. The statistical population consisted of all Urmia University faculty members, 217 of whom were selected as a statistical sample using the Georgia-Morgan table and by relative randomness for study. Research Tools includes Teacher's Self-efficacy questionnaire, Emotional exhaustion questionnaire, Teaching Motivation questionnaire, and Innovative Teaching questionnaire. After confirming the formal and content validity of the research tools by the experts, the validity of the structure through the confirmatory factor analysis at the first stage and the reliability of the research tool from Cronbach's alpha coefficient which is 0.91, 0.79, 0.80, and 0.77 was calculated respectively. Data was analyzed by SPSS26 and SmartPls3. The results showed that self-efficacy and teaching motivation had direct, positive and significant and Emotional exhaustion had a direct, negative and significant impact on innovative teaching. Therefore, it is suggested that in order to use innovative teaching more in universities by faculty members, more attention should be paid to the strengthening of their teacher self-efficacy and teaching motivation.